Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribers receive full online access to your subscription and archive of back issues up to and including 2002.
Content published before 2002 is available via pay-per-view purchase only.
Subscribe:
Subscribe to Anesthesiology ClinicsAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- New technologies for elucidating opioid receptor function.Trends Pharmacol Sci. 2016; 37: 279-289
- Tracing the US opioid crisis to its roots.Nature. 2019; 573: S10-S12
- Biased agonism in drug discovery-is it too soon to choose a path?.Mol Pharmacol. 2018; 93: 259-265
- Biased signaling: from simple switches to allosteric microprocessors.Nat Rev Drug Discov. 2018; 17: 243-260
- Conformational basis of g protein-coupled receptor signaling versatility.Trends Cell Biol. 2020; 30: 736-747
- Biased receptor signaling in drug discovery.Pharmacol Rev. 2019; 71: 267-315
- G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning.Sci Rep. 2017; 7: 7885
- The pharmacological basis of therapeutics: a textbook of pharmacology, toxicology, and therapeutics for physicians and medical students.1st ed. Macmillan Publishing, New York1941
- Opiate receptor: demonstration in nervous tissue.Science. 1973; 179: 1011-1014
- Critical assessment of g protein-biased agonism at the μ-opioid receptor.Trends Pharmacol Sci. 2020; 41: 947-959
- Biased mu-opioid receptor ligands: a promising new generation of pain therapeutics.Curr Opin Pharmacol. 2017; 32: 77-84
- Biased ligands at opioid receptors: Current status and future directions.Sci Signal. 2021; 14: eaav0320
- Arresting the development of addiction: the role of β -arrestin 2 in drug abuse.J Pharmacol Exp Ther. 2017; 361: 341-348
- Enhanced morphine analgesia in mice lacking beta-arrestin 2.Science. 1999; 286: 2495-2498
- Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.Nature. 2000; 408: 720-723
- Morphine side effects in beta-arrestin 2 knockout mice.J Pharmacol Exp Ther. 2005; 314: 1195-1201
- Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.J Neurosci. 1998; 18: 7285-7295
- Solving the opioid crisis: respiratory depression by opioids as critical end point.Chest. 2019; 156: 653-658
- Differential impact of two critical respiratory centres in opioid-induced respiratory depression in awake mice.J Physiol. 2020; 598: 189-205
- Opioids depress breathing through two small brainstem sites.Elife. 2020; 9: e52694
- Μ opioid receptor activation hyperpolarizes respiratory-controlling kölliker-fuse neurons and suppresses post-inspiratory drive.J Physiol. 2015; 593: 4453-4469
- Morphine-induced respiratory depression is independent of β-arrestin2 signalling.Br J Pharmacol. 2020; 177: 2923-2931
- Oliceridine: a novel drug for the management of moderate to severe acute pain - a review of current evidence.J Pain Res. 2021; 14: 969-979
- Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (Trv130), for the treatment of acute severe pain.J Med Chem. 2013; 56: 8019-8031
- Commissioner, O. FDA Approves New Opioid for Intravenous Use in Hospitals, Other Controlled Clinical Settings.(Available at:) (Accessed 1 October 2022)
- Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.Neuropharmacology. 2020; 166: 107718
- Pharmacological characters of oliceridine, a μ-opioid receptor g-protein–biased ligand in mice.Anesth Analg. 2019; 129: 1414-1421
- Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (Oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents.J Psychopharmacol. 2017; 31: 730-739
- APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (Trv130), a G protein-biased ligand at the μ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy.J Pain Res. 2019; 12: 927-943
- Apollo-2: a randomized, placebo and active-controlled phase iii study investigating oliceridine (Trv130), a g protein-biased ligand at the μ-opioid receptor, for management of moderate to severe acute pain following abdominoplasty.Pain Pract. 2019; 19: 715-731
- A randomized, Phase IIb study investigating oliceridine (Trv130), a novel μ-receptor G-protein pathway selective (Μ-gps) modulator, for the management of moderate to severe acute pain following abdominoplasty.J Pain Res. 2017; 10: 2413-2424
- Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.Sci Signal. 2020; 13: eaaz3140
- Treatment of chronic pain with various buprenorphine formulations: a systematic review of clinical studies.Anesth Analg. 2018; 127: 529-538
- A narrative pharmacological review of buprenorphine: a unique opioid for the treatment of chronic pain.Pain Ther. 2020; 9: 41-54
- Olinvyk [package insert]. Trevena Inc, Chesterbrook, PA2020
- Evidence for continuing buprenorphine in the perioperative period.Clin J Pain. 2020; 36: 764-774
- A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine.J Pharmacol Exp Ther. 2013; 344: 708-717
- Understanding the effect of different assay formats on agonist parameters: a study using the μ-opioid receptor.J Biomol Screen. 2011; 16: 706-716
- Efficacy and ligand bias at the μ-opioid receptor.Br J Pharmacol. 2013; 169: 1430-1446
- Assessment of structure-activity relationships and biased agonism at the Mu opioid receptor of novel synthetic opioids using a novel, stable bio-assay platform.Biochem Pharmacol. 2020; 177: 113910
- Desmetramadol is identified as a g-protein biased μ opioid receptor agonist.Front Pharmacol. 2019; 10: 1680
- Trends in tramadol: pharmacology, metabolism, and misuse.Anesth Analg. 2017; 124: 44-51
- Enhanced rewarding properties of morphine, but not cocaine, in beta(Arrestin)-2 knock-out mice.J Neurosci. 2003; 23: 10265-10273
- Abuse potential of biased mu opioid receptor agonists.Trends Pharmacol Sci. 2018; 39: 916-919
- Biased opioid ligands.Molecules. 2020; 25: 4257
- A first-in-human clinical study with trv734, an orally bioavailable g-protein-biased ligand at the μ-opioid receptor.Clin Pharmacol Drug Dev. 2020; 9: 256-266
- Synthetic and receptor signaling explorations of the mitragyna alkaloids: mitragynine as an atypical molecular framework for opioid receptor modulators.J Am Chem Soc. 2016; 138: 6754-6764
- Biased agonism: lessons from studies of opioid receptor agonists.Annu Rev Pharmacol Toxicol. 2023; 63: 491-515
- The G-protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signalling to ion channels.Br J Pharmacol. 2019; 176: 3110-3125
- Functional characterization of a novel opioid, PZM21, and its effects on the behavioural responses to morphine.Br J Pharmacol. 2019; 176: 4434-4445
- Abuse-deterrent opioid formulations.Anesthesiology. 2018; 128: 1015-1026
- The promotion and marketing of oxycontin: commercial triumph, public health tragedy.Am J Public Health. 2009; 99: 221-227
- Nktr-181: a novel mu-opioid analgesic with inherently low abuse potential.J Pharmacol Exp Ther. 2017; 363: 104-113
- A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates.Proc Natl Acad Sci U S A. 2016; 113: E5511-E5518
- Mu opioid pharmacology: 40 years to the promised land.Adv Pharmacol. 2018; 82: 261-291
- Safety benefits of ‘biased’ opioids scrutinized.Science. 2020; 367: 966
Article info
Publication history
Published online: March 15, 2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 Elsevier Inc. All rights reserved.