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Review Article| Volume 33, ISSUE 1, P79-91, March 2015

Pathophysiology of Major Surgery and the Role of Enhanced Recovery Pathways and the Anesthesiologist to Improve Outcomes

  • Michael J. Scott
    Correspondence
    Corresponding author. Department of Anesthesia and Perioperative Medicine, Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, Surrey, Guildford GU1 7XX.
    Affiliations
    Department of Anesthesia and Perioperative Medicine, Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, Surrey, Guildford GU1 7XX, United Kingdom

    Surrey Perioperative Anesthesia Critical Care Research Group (SPACeR), University of Surrey, Surrey, Guildford GU2 7XH, United Kingdom
    Search for articles by this author
  • Timothy E. Miller
    Affiliations
    Department of Anesthesiology, Duke University Medical Center, BOX 3094, HAFS 5677, Durham, NC 27710, USA
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      References

        • Fawcett W.J.
        • Mythen M.G.
        • Scott M.J.
        Enhanced recovery: more than just reducing length of stay?.
        Br J Anaesth. 2012; 109: 671-674
        • Khuri S.F.
        • Henderson W.G.
        • DePalma R.G.
        Determinants of long-term survival after major surgery and the adverse effect of postoperative complications.
        Ann Surg. 2005; 242: 326-341
        • Moonesinghe S.R.
        • Harris S.
        • Mythen M.G.
        • et al.
        Survival after postoperative morbidity: a longitudinal observational cohort study†.
        Br J Anaesth. 2014; ([Epub ahead of print])
        • Day A.R.
        • Middleton G.
        • Smith R.V.
        • et al.
        Time to adjuvant chemotherapy following colorectal cancer resection is associated with an improved survival.
        Colorectal Dis. 2014; 16: 368-372
        • Kehlet H.
        • Wilmore D.W.
        Evidence-based surgical care and the evolution of fast-track surgery.
        Ann Surg. 2008; 248: 189-198
        • Gustafsson U.O.
        • Scott M.J.
        • Schwenk W.
        • et al.
        Guidelines for perioperative care in elective colonic surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations.
        World J Surg. 2012; 37: 259-284
        • Lassen K.
        • Coolsen M.M.
        • Slim K.
        • et al.
        Guidelines for perioperative care for pancreaticoduodenectomy: Enhanced Recovery After Surgery (ERAS®) Society recommendations.
        Clin Nutr. 2012; 31: 817-830
        • Mortensen K.
        • Nilsson M.
        • Slim K.
        • et al.
        Consensus guidelines for enhanced recovery after gastrectomy: Enhanced Recovery After Surgery (ERAS®) Society recommendations.
        Br J Surg. 2014; 101: 1209-1229
        • Cerantola Y.
        • Valerio M.
        • Persson B.
        • et al.
        Guidelines for perioperative care after radical cystectomy for bladder cancer: Enhanced Recovery After Surgery (ERAS(®)) society recommendations.
        Clin Nutr. 2013; 32: 879-887
        • Nygren J.
        • Thacker J.
        • Carli F.
        • et al.
        Guidelines for perioperative care in elective rectal/pelvic surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations.
        World J Surg. 2013; 37: 285-305
        • Maessen J.
        • Dejong C.H.
        • Hausel J.
        • et al.
        A protocol is not enough to implement an enhanced recovery programme for colorectal resection.
        Br J Surg. 2007; 94: 224-231
        • Gustafsson U.O.
        • Hausel J.
        • Thorell A.
        • et al.
        Adherence to the enhanced recovery after surgery protocol and outcomes after colorectal cancer surgery.
        Arch Surg. 2011; 146: 571-577
        • Stephan R.N.
        • Kupper T.S.
        • Geha A.S.
        • et al.
        Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis.
        Arch Surg. 1987; 122: 62-68
        • Ayala A.
        • Perrin M.M.
        • Meldrum D.R.
        • et al.
        Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin.
        Cytokine. 1990; 2: 170-174
        • Levy B.F.
        • Fawcett W.J.
        • Scott M.J.
        • et al.
        Intra-operative oxygen delivery in infusion volume-optimized patients undergoing laparoscopic colorectal surgery within an enhanced recovery programme: the effect of different analgesic modalities.
        Colorectal Dis. 2012; 14: 887-892
        • Demyttenaere S.
        • Feldman L.S.
        • Fried G.M.
        Effect of pneumoperitoneum on renal perfusion and function: a systematic review.
        Surg Endosc. 2007; 21: 152-160
        • Schröder W.
        • Stippel D.
        • Gutschow C.
        • et al.
        Postoperative recovery of microcirculation after gastric tube formation.
        Arch Surg. 2004; 389: 267-271
        • Gould T.H.
        • Grace K.
        • Thorne G.
        • et al.
        Effect of thoracic epidural anaesthesia on colonic blood flow.
        Br J Anaesth. 2002; 89: 446-451
        • Brandi L.S.
        • Frediani M.
        • Oleggini M.
        • et al.
        Insulin resistance after surgery: normalization by insulin treatment.
        Clin Sci. 1990; 79: 443-450
        • Frioud A.
        • Comte-Perret S.
        • Nguyen S.
        • et al.
        Blood glucose level on postoperative day 1 is predictive of adverse outcomes after cardiovascular surgery.
        Diabetes Metab. 2010; 36: 36-42
        • Egi M.
        • Finfer S.
        • Bellomo R.
        Glycemic control in the ICU.
        Chest. 2011; 140: 212-220
        • NICE-SUGAR Study Investigators
        • Finfer S.
        • Chittock D.R.
        • et al.
        Intensive versus conventional glucose control in critically ill patients.
        N Engl J Med. 2009; 360: 1283-1297
        • Sheeran P.
        • Hall G.M.
        Cytokines in anaesthesia.
        Br J Anaesth. 1997; 78: 201-219
        • Carli F.
        • Halliday D.
        Continuous epidural blockade arrests the postoperative decrease in muscle protein fractional synthetic rate in surgical patients.
        Anesthesiology. 1997; 86: 1033-1040
        • Mayo N.E.
        • Feldman L.
        • Scott S.
        • et al.
        Impact of preoperative change in physical function on postoperative recovery: argument supporting prehabilitation for colorectal surgery.
        Surgery. 2011; 150: 505-514
        • Francis N.
        • Kennedy R.H.
        • Ljungqvist O.
        • et al.
        Manual of fast track recovery for colorectal surgery.
        in: Francis N. Kennedy R.H. Ljungqvist O. Springer Science & Business Media, London2012
        • Varadhan K.K.
        • Neal K.R.
        • Dejong C.H.
        • et al.
        The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: a meta-analysis of randomized controlled trials.
        Clin Nutr. 2010; 29: 434-440
        • Chambers D.
        • Paton F.
        • Wilson P.
        • et al.
        An overview and methodological assessment of systematic reviews and meta-analyses of enhanced recovery programmes in colorectal surgery.
        BMJ Open. 2014; 4: e005014
        • Scott M.J.P.
        • Levy B.F.
        • Rockall T.A.
        • et al.
        23-hour-stay laparoscopic colectomy.
        Dis Colon Rectum. 2009; 52: 1239-1243
        • Jones C.
        • Kelliher L.
        • Dickinson M.
        • et al.
        Randomized clinical trial on enhanced recovery versus standard care following open liver resection.
        Br J Surg. 2013; 100: 1015-1024
        • Markar S.R.
        • Karthikesalingam A.
        • Low D.E.
        Enhanced recovery pathways lead to an improvement in postoperative outcomes following esophagectomy: systematic review and pooled analysis.
        Dis Esophagus. 2014; ([Epub ahead of print])
        • Veenhof A.A.
        • Vlug M.S.
        • van der Pas M.H.
        • et al.
        Surgical stress response and postoperative immune function after laparoscopy or open surgery with fast track or standard perioperative care: a randomized trial.
        Ann Surg. 2012; 255: 216-221
        • Ren L.
        • Zhu D.
        • Wei Y.
        • et al.
        Enhanced Recovery After Surgery (ERAS) program attenuates stress and accelerates recovery in patients after radical resection for colorectal cancer: a prospective randomized controlled trial.
        World J Surg. 2012; 36: 407-414

      Linked Article

      • Erratum
        Anesthesiology ClinicsVol. 33Issue 4
        • Preview
          In the March 2015 issue of Anesthesiology Clinics (Volume 33, Issue 1), in the article “Pathophysiology of Major Surgery and the Role of Enhanced Recovery Pathways and the Anesthesiologist to Improve Outcomes” by Michael J. Scott and Timothy E. Miller, the source of Figure 1 was excluded from the figure legend. Figure 1 originally appeared in Critical Care Clinics (Volume 26, Issue 3) in the article “Enhanced Recovery After Surgery: The Future of Improving Surgical Care” by Krishna K. Varadhan, Dileep N.
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